Penambahan Magnesium Oksida (MgO) Terhadap Sifat Sintesis Hidroksiapatit Berpori

Firmansyah Sophian Putra

Authors

Firmansyah Sophian Putra Universitas Pembangunan Nasional “Veteran” Jawa Timur Author

Keywords:

hydroxyapatite, magnesium oxide, additives, biomedical application

Abstract

Hydroxyapatite (HAp) is a bioceramic material widely used in the medical field, especially as a bone filler for bone tissue regeneration. However, pure HAp has low mechanical strength so that material modification is required. This study aims to examine the effect of the addition of Magnesium Oxide (MgO) and Polyvinyl Alcohol (PVA) on the morphological characteristics, functional groups, pore size, porosity, and Ca/P content of porous hydroxyapatite synthesized by the precipitation method. Variations in the weight percentage of MgO (14–18% wt) and the ratio of distilled water and Polyvinyl Alcohol (PVA) solution (20–60%) were used in the preparation of porous hydroxyapatite. Characterization includes spectrophotometric tests to analyze Ca/P content, morphological tests using SEM, functional group analysis using FTIR, and surface area analysis using BET. Based on the results of the test analysis that has been carried out, it is known that the porous hydroxyapatite sample with a variation of 1,8% MgO addition and 40% PVA ratio has a Ca/P value of 1,67 and has good characteristics for biomaterial applications with a granular morphological structure surface area of 7.3849 m2/g with an average pore size of 2.0274 nm, and is not toxic to health.

References

[1] A. Barfeie, J. Wilson, and J. Rees, “Implant surface characteristics and their effect on osseointegration,” Mar. 13, 2015, Nature Publishing Group. doi: 10.1038/sj.bdj.2015.171.

[2] Ghassemi, Toktam, et al. "Current concepts in scaffolding for bone tissue engineering." Archives of bone and joint surgery 6.2 (2018): 90.

[3] V. S. Bystrov, E. V. Paramonova, L. A. Avakyan, N. V. Eremina, S. V. Makarova, and N. V. Bulina, “Effect of Magnesium Substitution on Structural Features and Properties of Hydroxyapatite,” Materials, vol. 16, no. 17, Sep. 2023, doi: 10.3390/ma16175945.

[4] S. K. Padmanabhan et al., “Mechanical and biological properties of magnesium-and silicon-substituted hydroxyapatite scaffolds,” Materials, vol. 14, no. 22, Nov. 2021, doi: 10.3390/ma14226942.

[5] C. C. Coelho et al., “The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute,” Sci Rep, vol. 10, no. 1, Dec. 2020, doi: 10.1038/s41598-020-76063-9.

[6] F. Kurniasari, “Pengaruh Penambahan Zat Aditif MgO Nanopartikel Terhadap Karakteristik Hidroksiapatit Berpori Sebagai Bone Filler.,” Physycs, Universitas Airlangga, Surabaya, 2015.

[7] P. Panyasiri, N. T. Lam, and P. Sukyai, “The Effect of Hydroxyapatite Prepared by In Situ Synthesis on the Properties of Poly (Vinyl Alcohol)/Cellulose Nanocrystals Biomaterial,” Journal of Polymers and the Environment, vol. 28, pp. 141–151, 2019.

[8] E. Fiume, G. Magnaterra, A. Rahdar, E. Verné, and F. Baino, “Hydroxyapatite for biomedical applications: A short overview,” Dec. 01, 2021, MDPI. doi: 10.3390/ceramics4040039.

[9] A. Forouzesh, F. Forouzesh, S. S. Foroushani, A. Forouzesh, and E. Zand, “A new method for calculating copper content and determining appropriate copper levels in foods,” Revista Chilena de Nutricion, vol. 48, no. 6, pp. 862–873, Dec. 2021, doi: 10.4067/S0717-75182021000600862.

[10] Pudjiastuti, Aida Rachman. "Preparasi hidroksiapatit dari tulang sapi dengan metode kombinasi ultrasonik dan spray drying." Universitas Indonesia, Depok (2014).

[11] S. Hossain and S. Ahmed, “FTIR spectrum analysis to predict the crystalline and amorphous phases of hydroxyapatite: a comparison of vibrational motion to reflection,” RSC Adv, vol. 13, no. 21, pp. 14625–14630, May 2023, doi: 10.1039/d3ra02580b.

[12] C. C. Coelho, L. Grenho, P. S. Gomes, P. A. Quadros, and M. H. Fernandes, “Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment,” Sci Rep, vol. 9, no. 1, Dec. 2019, doi: 10.1038/s41598-019-47491-z.

[13] S. Joschek, B. Nies, R. Krotz, and A. Göpferich, “Chemical and physicochemical characterization of porous hydroxyapatite ceramics made of natural bone,” Biomaterials, vol. 21, no. 16, pp. 1645–1658, 2000.

[14] Azkiyah, Fardatul. Optimalisasi Variasi Komposisi Penambahan Zno Nanopartikel Terhadap Karakteristik Hidroksiapatit Berpori Sebagai Bone Filler. Diss. Universitas Airlangga, 2015.

[15] M. Trzaskowska et al., “Biocompatible nanocomposite hydroxyapatite-based granules with increased specific surface area and bioresorbability for bone regenerative medicine applications,” Sci Rep, vol. 14, no. 1, Dec. 2024, doi: 10.1038/s41598-024-79822-0.

[16] W. L. Xu et al., “Effect of heat-treatment on microstructure of hydroxyapatite porous microspheres for enhanced biocompatibility,” Journal of Saudi Chemical Society, vol. 29, no. 3, Jul. 2025, doi: 10.1007/s44442-025-00010-4.

[17] McNaught, Alan D., and Alan D. McNaught. Compendium of chemical terminology. Vol. 1669. Oxford: Blackwell Science, 1997.

[18] R. Rial, M. González‐durruthy, Z. Liu, and J. M. Ruso, “Advanced materials based on nanosized hydroxyapatite,” Jun. 01, 2021, MDPI AG. doi: 10.3390/molecules26113190.