Literatur Review : Sintesis Hidroksiapatit Dari Limbah Tulang Sapi Menggunakan Metode Hidrotermal

Etih Hartati; Khoirunisa Ameilia Rahmawati; Djaenudin; Herlian Eriska Putra

Authors

Etih Hartati Institut Teknologi Nasional Author
Khoirunisa Ameilia Rahmawati Institut Teknologi Nasional Author
Djaenudin Pusat Riset Teknologi Bersih, Badan Riset dan Inovasi Nasional Author
Herlian Eriska Putra Pusat Riset Teknologi Bersih, Badan Riset dan Inovasi Nasional Author

Keywords:

Hidroksiapatit, Hidrotermal, bovine bone waste, denture

Abstract

Indonesia is one of the countries with high beef consumption and production, resulting in large amounts of bone waste, especially rib bones, every year. This bone waste is generally not optimally utilized and has the potential to cause environmental problems. In fact, cow bones, including ribs, contain a high-value mineral compound called hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂). Hydroxyapatite is an inorganic compound with a crystal structure and composition similar to human bone and tooth tissue, making it a highly potential material in the biomedical field, especially as a raw material for dentures, bone implants, and bone fillers. Through environmentally friendly technological approaches such as the hydrothermal method, bone waste can be processed to extract pure hydroxyapatite. This process involves heat and pressure treatment in a closed device that can remove organic components without damaging the mineral structure. The synthesized hydroxyapatite has a composition and crystal structure similar to human hard tissue, making it highly potential for use as a base material in medical applications, especially for dental prostheses.

References

[1] H. A. Suratman, H. P. Wijaksono, H. and S. Fauziyah, "Pemanfaatan Limbah Tulang Sapi dan Kaca Sebagai Substitusi Parsial Semen Terhadap Bata Beton Pejal," Jurnal Sipil dan Arsitektur, pp. 46-54, 2023.

[2] M. S. Haruda, A. Fadli and S. R. Yenti, "Pengaruh pH dan Waktu Reaksi Pada Sintesis Hidroksiapatit dari Tulang Sapi dengan Metode Presipitasi," Jurnal Online Mahasiswa (JOM) Fakultas Teknik, Universitas Riau, p. Volume 3, 2016.

[3] M. S. Hossain, M. N. Uddin, S. Sarkar and S. Ahmed, "Crystallographic Dependency of Waste Bone, Hydrocyapatite, and B-Tricalcium Phospate for Biomedical Application," Journal of Saudia Chemical Society, 2022. [4] A. M. Elhadad, Pengaruh Suhu Hidrotermal dalam Sintesis dan Karakterisasi Hidroksiapatit dengan Memanfaatkan Potensi Udang Papai (Acetes Erythraeus) Sebagai Sumber Kalsium, Jambi: Universitas Jambi, 2021.

[5] A. F. Setiawan, "Pengaruh Natrium Hidroksida Pada Sintesis Hidroksiapatit Dari Tulang," Jurusan Teknik Mesin, Fakultas Teknik, Universitas Negeri Surabaya, pp. 41-148, 2023.

[6] A. B. Wijanarko and M. A. Irfa'i, "Studi Temperatur Hidrotermal Pada Sintesis Hidroksiapatit yang Berasal dari Tulang Sapi Untuk Aplikasi Biomaterial," Jurnal Teknik Mesin (JTM), Fakultas Teknik, Universitas Negeri Surabaya, p. Volume 12 Nomor 1, 2023.

[7] Alimuddin and S. Rahayu, "Eksplorasi Limbah Tulang Sapi sebagai Sumber Biomaterial Hidroksiapatit," Kappa Journal, pp. 357-365, 2019.

[8] F. Afifah and S. E. Cahyaningrum, "Sintesis Dan Karakterisasi Hidroksiapatit dari Tulang Sapi (Bos Taurus) Menggunakan Teknik Kalsinasi Synthesis nd Characterization Of Hydroxyapatite Ffrom Cow Bones (Bos Taurus) Using Calcination Techniques," UNESA Journal of Chemistry, pp. 189-196, 2020.

[9] F. Fitriyana , R. Ismail, A. P. Bayuseno, J. P. Siregar and T. Cionata, "Characterization of Hydroxyapatite Extracted from Crab Shell Using the Hydrothermal Method with Varying Holding Times," Journal of Renewable Materials, pp. 1145-1163, 2024.

[10] M. N. A. S. Puad, P. Koshy, H. Z. Abdullah, M. I. Idris and T. C. Lee, "Syntheses of Hydroxyapatite from Natural sSurces," Elsevier , pp. 1-14, 2019.

[11] A. B. Wijanarko and M. A. Irfa'i, "Studi Temperatur Hidrotermal Pada Sintesis Hidroksiapatit yang Berasal dari Tulang Sapi Untuk Aplikasi Biomaterial," JTM , pp. 1-6, 2023.

[12] Ikhsan, Gunawarman and Y. Yetri, "Karakteristik Hidroksiapatit (HA) Dari Limbah Tulang Sapi dengan Metode Mekanik-Termal," Poli Rekayasa, pp. 43-53, 2018.

[13] M. Rana, S. Akhtar, H. M. Rahman, Jarnil and Asadubazzaman, "Extraction of Hydroxyapatite from Bovine and Human Cortical Bone by Thermal Decomposition and Effect of Gamma Radiation: A Comparative Study," International Journal of Complementary and Alternative Medicine, pp. 1-2, 2017.

[14] V. Amalia, E. P. Hadisantoso, Hidayat, Diba, Dermawan and Tsaniyah, "Isolasi dan Karakterisasi Hidroksiapatit dari Limbah Tulang Hewan.," ALCHEMY Journal of Chemistry, pp. 114-115, 2017.

[15] M. N. Hossain, Uddin, S. Sarkar and S. Ahmed, "Crystallographic Dependency of Wate Cow Bone Hydroxyapatite and Tricalcium Phosphate for Biomedical Application," Journal of Saudi Chemical Society , 2022.

[16] F. Afifah and S. E. Cahyaningrum, "Synthesis and Characterization of Hydroxyapatite from Cow Bones (Bos Taurus) Using Calcination Techniques," UNESA Journal of Chemistry, pp. 189-196, 2020.

[17] E. Kusrini and M. Sontang, "Characterization of X-Ray Diffraction and Electron Spin Resonance: Effects of Sintering Time and Temperature on Bovine Hydroxyapatite," Radiation Physics and Chemistry, pp. 118-125, 2017.

[18] S. Kusnieruk, E. Wojnarowska, J. Szaniawska and J. Grezesiak, "Influence of Hydrothermal Synthesis Parameters on the Properties of Hydroxyapatite Nanoparticles," Beilstein Journal of Nanotechnology, pp. 1586-1601, 2016.

[19] S. George, D. Mehta and V. K. Saharan, "Application of Hydroxyapatite and its Modified form as Adsorbents for Water Defluoridation: An Insight Into Pocess Synthesis," Reviews in Chemical Engineering, pp. 369-400, 2020.

[20] Parahita, I. Simpen and N. M. Suastuti, "Ekstraksi dan Karakterisasi Hidroksiapatit dari Limbah Kerajinan Tulang Sapi Menggunakan Metode Kombinasi Kalsinasi dan Refluks," Jurnal Kimia (Journal of Chemistry), 2016.

[21] J. Khotib , M. A. Gani , A. S. Budiatin, M. L. A. D. Lestari, E. Rahadiansyah and Ardianto, "Signaling Pathway and Transcriptional Regulation in Osteoblasts During Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial," Pharmaceuticals, p. 615, 2021.

[22] J. K. Odusote, Y. Danyou, A. D. Baruwa and A. A. Azeez, "Synthesis and Characterization of Hydroxyapatite from Bovine Bone for Production of Dental Implants," Journal of Applied Biomaterials & Functional Materials, 2019.

[23] A. H. Dom, S. Rezadin and T. A. Rahim, "Influence of Calcination Temperature on the Physicochemical Properties of Synthesized Hydroxyapatite from Cow Bone Waste," Journal of Advanced Research in Micro and Nano Engineering, pp. 115-127, 2024.

[24] M. Sundareswari, K. Ravichandran, M. B. Latha and S. Sagedavan, "Tailoring the Morphological Features of Sol–Gel Synthesized Mesoporous Hydroxyapatite Using Fatty Acids as an Organic Modifier," Royal Society of Chemistry, pp. 6228-6240, 2019.

[25] A. R. Noviyanti, "Pembuatan Komposit Hidroksiapatit-Titanium Dioksida dari Tulang Sapi dengan Metode Hidrotermal," Crystals, p. 1599, 2022.

[26] D. Asmi, "Sintesis dan Karakterisasi Biohidroksiapatit dari Tulang Sapi," Jurnal Semirata, 2020.